Muller's ratchet

If you are a scientist and want to quantify the effects of Muller's ratchet in your favourite model system, this page will help you.

The principle of Muller’s ratchet: The main effect of Muller’s ratchet is the accumulation of slightly harmful DNA changes in a population over many generations. This can lead to the extinction of species and is thus of considerable biological interest.
How to quantify effects of Muller's ratchet: Evolution@home has compiled the largest existing database of Muller's ratchet simulation results. This allows quantifications of the threat of extinction from Muller's ratchet with unprecedented accuracy as well as other aspects. Depending on what you know about your favorite organism, these results might help to work out what the ratchet does there.